Parabens inhibit fatty acid amide hydrolase: A potential role in paraben-enhanced 3T3-L1 adipocyte differentiation
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چکیده
منابع مشابه
MicroRNA and 3T3-L1 pre-adipocyte differentiation.
MicroRNAs (miRNAs) have been suggested to play important roles in cell proliferation, apoptosis, and differentiation. In this study, we examined miRNA expression profiles during 3T3-L1 pre-adipocyte differentiation. We constructed miRNA libraries from pre- and post-differentiated 3T3-L1 cells, and identified the expression of 77 previously reported miRNAs and 3 new miRNAs. Next, we investigated...
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The activity, content, and turnover of the key lipogenic enzyme fatty acid synthetase were studied during the differentiation of 3T3-Ll preadipwytes into adipocytes. The specific activity of the enzyme began to rise sharply when triglyceride droplets were first detected in the cells (Day 3) and ultimately increased 13-fold to a new steady state level in adipocytes 7 days after the initiation of...
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BACKGROUND Obesity and metabolic syndrome are important public concerns, and there is increasing demand for effective therapeutic strategies. Flavonoids are expected to improve the risk factors associated with metabolic syndrome. Anthocyanidins are a kind of flavonoids; well known for their anti-oxidative, anti-inflammatory and anti-tumor properties. However, their effects on adipocytes and mol...
متن کاملFatty acid amide hydrolase substrate specificity.
Fatty acid amide hydrolase (FAAH), also referred to as oleamide hydrolase and anandamide amidohydrolase, is a serine hydrolase responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers. FAAH hydrolyzes a range of fatty acid amides, and the present study examines the relative rates of hydrolysis of a variety of natural and unnat...
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ژورنال
عنوان ژورنال: Toxicology Letters
سال: 2016
ISSN: 0378-4274
DOI: 10.1016/j.toxlet.2016.09.011